PhD Scholarship Neuropeptide Signaling in Blood Vessel Assembly and Maintenance

A new PhD position in life sciences is available at The University of Queensland. Applicants should apply before September 26, 2019.

IMB is a global leader in multidisciplinary life sciences research, bringing together 500 researchers from across the globe for disease discovery, application and sustainable futures.

Formed in 2000 as an initiative of The University of Queensland, State and Federal Governments and private philanthropy, IMB is one of the largest life sciences institutes in the Asia-Pacific region. It has capitalised on one of the greatest periods of discovery in history - the genetic and molecular basis of life and its diversity.

A major function of the endothelial cells (ECs) that line our entire vessel network is to form a barrier between the blood and surrounding tissues. Altered barrier function contributes to a range of pathologies including haemorrhagic stroke and cancer. Adhesion molecules that connect ECs at junctions are of great importance to control vessel barriers. Intercellular engagement by adhesion molecules is extremely dynamic in space and time, depending on the requirements of the surrounding tissue. Developing capabilities to manipulate vascular adhesion is a major therapeutic goal. In this project we aim to understand the role of a neuropeptide family that is known to impact on a range of cardio-vascular diseases like hypertension and heart failure. The degree to which these peptides control vascular adhesion in vivo and precise mechanism of action however remain unknown. Our preliminary data has yet implicated a novel, specific, role for these peptides in the formation of venous vessel beds but not arteries by live analysis of zebrafish mutant models. This is a uniquely specific phenotype that has not been previously identified. For this PhD project we will use zebrafish mutants and bioengineered human micro-vessels to understand the molecular mechanisms by which these peptides regulate adhesion in functional vasculature with unprecedented resolution. Applicants should have the following: First class Honours or equivalent; and To be eligible to apply, you must also meet the entry requirements for Higher Degrees by Research at UQ. Please visit theGraduate School’s website.

To be considered for this scholarship, pleaseemailthe following documents to Dr AK Lagendijk at a.lagendijk@imb.uq.edu.au

Please note the following: Submitting the above documents does not constitute a full application for admission into The University of Queensland’s PhD program. If you are selected as the preferred applicant, you will then be invited to submit a full application for admission. You can familiarise yourself with the documents required for thisprocess on the Graduate School’s website.

Deadline: September 26, 2019
Apply Link:http://tinyurl.com/y3np5gm7

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