PhD Scholarship in Computational Cancer Genomics Using Liquid Biopsies

University of Helsinki, Finland is inviting excellent candidates to apply for a PhD position in molecular biology. This position is available for 4 years. Eligible candidates should submit the applications before September 20, 2019.

Come to build future of personalized cancer care with us!

The Systems Biology of Drug resistance Cancer https://www.helsinki.fi/en/researchgroups/systems-biology-of-drug-resist… invites applications for a position for

starting preferably in the fall 2019. You will work in the project "Computational methods to identify clinically actionable alterations from liquid biopsies in chemotherapy resistant ovarian cancer" funded by the Academy of Finland until 31.8.2023.

Organization: University of Helsinki, Faculty of Medicine

Research Field: Computational cancer research Researcher Profile: PhD student Application Deadline: Latest 20/09/2019, will be filled when suitable candidate is found Duration: 4 years Location: Finland, Helsinki Project description

You will develop novel state-of-the-art methodology and analysis approaches to identify clinically applicable information from cancer patients’ liquid biopsies such as circulating tumor DNA (ctDNA). Continuous series of blood samples provide easy access tumor mutation status. On-line genetic profiling enables gathering processes of tumor evolution reasons for chemoresistance which eventually enables early detection of relapse and assigning the best treatments individually for each patient. Your project's main focus is on high-through-put sequencing data. You will be part of a bioinformatics focused team and will develop pipelines and protocols for ctDNA data and integration with other data types.

You have

-Good computational skills, such as programming with R, Python or similar. -Basic knowledge on biology and/or genetics. -Experience in computational genomics or molecular cancer research will be an asset. -Enthusiastic attitude towards science and good teamwork skills. -Fluent written and spoken English. -Master's degree (or soon to graduate) We offer

-International multidisciplinary research environment with state-of-the-art facilities. -Exceptional opportunity to work together with highly skilled group members and collaborators with complementary expertise in biochemistry, molecular biology, genetics, high-throughput molecular technologies, genetics, mathematical and computational modelling, and clinical oncology. -PhD project in the Systems Biology of Drug Resistance in Cancer research group. Laboratory is part of Systems Oncology (ONCOSYS) Research Program, both led by Professor Sampsa Hautaniemi. The overall common objective is to understand causes of cancer progression and treatment resistance. We have already collected hundreds of plasma samples for ctDNA extraction. We have published pilot part of the study to show that ctDNA can be used to guide treatment in ovarian cancer (https://ascopubs.org/doi/10.1200/PO.18.00343).

Place

The Faculty of Medicine promotes scientific research of a high standard. In terms of research, the Faculty aims for a place among the best medical faculties in the world, while consolidating and strengthening its status as a top-level institution of medical education. Together with the Helsinki University Hospital (HUS) and the Helsinki Institute of Life Sciences (HiLIFE), the Faculty of Medicine, University of Helsinki, constitutes the Academic Medical Center Helsinki (AMCH). This medical center has been very successful in international comparisons, ranking among the top 10 medical campuses in Europe and among the top 50 globally. Research Programs unit of the Faculty of Medicine is a top-quality research environment. Systems Oncology (ONCOSYS) Research Program is one of the unit's nine research programs, which comprise groups that integrate clinical, translational and biomedical research.

Biomedicum Helsinki is placed in the capital of Finland and provides a home for over 2300 researchers. It is the leading environment of biomedical research in Finland and supports collaborations between academy and industry.

www.helsinki.fi/university/

Application

The application should include a short cover letter describing your areas of expertise and motivation for the position, CV, list of publications, and names and contact information of two to three references. The application, together with the required attachments, must be submitted through the University of Helsinki electronic recruitment system by clicking on Apply for job. Internal applicants (i.e., current employees of the University of Helsinki) must submit their applications through the SAP HR portal. Additional information

Initial contract of employment will be done for a minimum of two years and the starting date is to be agreed, preferably in fall 2019. A trial period of six months will be applied. Salary will be based on the Universities salary scheme for teaching and research personnel composed of both task specific (level 2) and personal performance components. Further information is available from Sampsa Hautaniemi, sampsa.hautaniemi(at)helsinki.fi, Tel. +358 50 336 4765.

Deadline: September 20, 2019
Apply Link:http://tinyurl.com/y3x4vhth

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