Postdoc Position Focused on Bacterial Secretion Systems

Imperial College London is offering postdoctoral scholar position in molecular biology. This position is available for 36 months. The deadline to apply is June 24, 2019.

We are seeking to recruit three outstanding structural biologists to join the group of Dr Harry Low, Department of Life Sciences. The research project focuses on determining the molecular mechanism of bacterial secretion systems including the type 2 secretion system and other significant macromolecular membrane complexes. Methodology will include cryo-electron microscopy (EM) and a suite of biophysical, biochemical and cellular assays to determine structure and function. The positions are funded by the Wellcome Trust.

You will be expected to take a leading role in studying the bacterial type 2 secretion system and other macromolecular complexes such as the type 4 pilus system. Structure and functional studies will be undertaken with an emphasis on taking advantage of the recent resolution revolution in cryo-EM. At times, you will mentor junior biochemists/structural biologists in our research team.

You will have a PhD (or equivalent) in structural biology, either cryo-EM, X-ray crystallography or NMR. Experience in cryo-EM and working with membrane complexes is advantageous. Experience in the design and execution of workflow for structure determination of proteins, from molecular biology/biochemical experiments (e.g. DNA cloning and mutagenesis, protein purification) through to structural data collection, analysis and model building is expected. You must have a strong research track record demonstrated by first author publications in international journals.

Excellent verbal and written communication skills, and the ability to write clearly and succinctly for publication is essential. You will relate well with others, form positive relationships with a wide range of people and work as part of a team, as well as independently. The ability to develop and apply new concepts and have a creative approach to problem-solving, to set and attain research objectives in a multidisciplinary team are also essential.

This is a full-time, fixed-term appointment available for 36 months initially with possibility of extension for a further 24 months.

*If you have not yet been awarded your PhD, you be appointed as a Research Assistant within the salary range 34,397-37,486 per annum.

To informally the discuss the vacany please email Dr. Harry Low at

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published.For more information, see

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College's care are treated with full respect, and that all staff involved with this work show due consideration at every level.

Deadline: June 24, 2019
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