PhD Scholarship in Medical Science Study Mycn Mediated Oncogenesis in Neuroblastoma

Applicants are invited to apply for a PhD position in molecular biology at University of Gothenburg. The funds for this fellowship are available for four years. This position is closed on June 04, 2019.

Third-cycle studies are equivalent to four year full-time and lead to a Degree of Doctor. Those appointed to doctoral studentships shall primarily devote themselves to their studies. Those appointed to doctoral studentships may, however, work to a limited extent with educational tasks, research and administration. Before a PhD degree has been awarded,duties of this kind may not comprise more than 20 per cent of a full-time post.

The PhD educationin Medical Science comprisecarrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://medarbetarportalen.gu.se/sahlgrenskaakademin/forskarutbildning/languageId=100001

Project: We are seeking an enthusiastic and highly motivated graduate student who has interest in cancer biology with focus on Neuroblastoma (NB). NB is a childhood cancer which thought to derive because of improper differentiation of trunk neural crest cells (tNCCs) which form the sympatho-adrenergic lineage. MYCN is frequently amplified in high risk NBs but it is not properly understood how MYCN cause the early transformation in the tNCCs. The proposed project will explore biology and molecular mechanism of MYCN mediated oncogenesis in NB using combination of cell biology and molecular biology technique. The Laboratory has prior expertise on studying gene regulation by epigenetic modifications and by long non-coding RNAs (lncRNAs), the candidate will use these available methodologies to understand MYCN mediated gene regulation.

The candidate willhave the opportunity to work in an excellent academic environment and will also be able to collaborate to other laboratory as and when required during the project. Method used include cell culture (embryonic stem cells and neuroblastoma cells), CRISPR/cas9 mediated genome editing, RNA-sequencing, epigenomics, molecular biology and biochemical techniques.

Relevant publications to the project: PMID: 29533783, 26205790, 29491376, 25517750

To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.

for third-cycle studiesif he or she:

1. has been awarded a second-cycle qualification 2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or 3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad for third-cycle studiesin Medical Science if he or she: has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:

– specific knowledge and skills within the subject area and related research fields – experience of scientific theory and relevant research methodology – scientific analysis and presentation verified through thesis, degree project, scientific journals or the like. Documented experience of laboratory knowledge, as well as knowledge of culturing embryonic stem cells, RNA biology technique, techniques related to study epigenetics is meritorious. Good communication skills are desired.

After admission tothird-cyclestudies you will be appointedtodoctoral studentship. Regulations for employment of doctoral students are given in SFS 1993:100. The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. A person may beappointed to a doctoral studentship for a total ofeight years. The total employment period may, however, not exceed the time corresponding to full-time third-cycle study for four years.

Location: Sahlgrenska Academy, Institute of Biomedicine,Department ofMedical Biochemistry and Cell Biology

Extent:100%. First day of employment: as agreed. Salaries for doctoral students are regulated in a local agreement at the University.

Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.

You must include the following, in pdf format

If your degree is from a university outside of Sweden, check what you need to submit at https://www.universityadmissions.se/en/All-you-need-to-know1/Applying-for-studies/Documenting-your-eligibility-for-studies/Instructions-for-Masters-applicants/Specific-requirements-for-my-country1/ where you can also see what you need to submit in order to fulfill the English language requirement.

The University of Gothenburg promotes equal opportunities, equality and diversity.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

Deadline: June 04, 2019
Apply Link:http://tinyurl.com/y62rlbnf

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