PhD Scholarship in Correlative Mass Spectrometry Imaging and Super-resolution Microscopy on The Molecular Turnover of Neuronal Stem Cells

Applicants are invited to apply for a PhD scholarship in medicinal chemistry at University of Gothenburg. The funds for this position are available for 5 years. The deadline for applying is June 15, 2019.

PhD student in correlative mass spectrometry imaging and super-resolution microscopy on the molecular turnover of neuronal stem cells

Research and graduate education at the department of chemistry and molecular biology comprises a wide scientific field from the atomic and molecular levels all the way through cells to intact organisms. Much of the phenomena studied here impact on our natural environment and living systems. We participate in undergraduate programs in chemistry, molecular biology, medicinal chemistry, biology, marine sciences, and pharmacy.

A third cycle education at our department will lead to a Ph.D. in Natural sciences, or Natural sciences with a specialisation in Chemistry, Biology or Biophysics. Ph.D. studies comprises four years at the post graduate level. The time period can be extended to 5 years in total through teaching and/or other departmental duties.

Dr. Phan's research interest has been focused on the development and application of multimodal imaging using mass spectrometry imaging, fluorescence microscopy, and electron microscopy to cells and neurobiology, particularly the study of the structural effects of psychostimulant drugs on the brain chemistry, and the molecular turnover of nerve cells and the brain. Her current interest is the correlation of nanoscale secondary ion mass spectrometry (nanoSIMS) and super-resolution fluorescence microscopy (STED) to study the structural and functional relationship between cellular lipids and proteins at subcellular and molecular levels. She is also working to develop labeling probes for specific targeted bio-imaging using these combined modalities.

See also http://andrewewinggroup.se for collaborative research group.

The PhD student will take classes and work on research projects in the laboratory to combine STED super-resolution microscopy, and mass spectrometry imaging (nanoSIMS, ToF-SIMS) to study the turnover of proteins and lipids in dopaminergic neuronal stem cells. The aim of the project is to understand the molecular mechanism and chemical cues that trigger the differentiation of the pluripotent stem cells (iPSC) into neuronal cells. We hypothesize that the molecular structure of the cells is functionally driven during cell differentiation and proliferation. Progenitor cells will be labelled with isotopic precursors of proteins, and lipids to track the spatial organization of their turnover at different time periods of the differentiation. Different protein markers which are specific for each differentiation stage will be labelled and visualized with STED microscopy. Correlation between the lipid turnover and protein localization on the same stem cells will be performed using our newly developed dual labelling probes for nanoSIMS and STED microscopy to study the formation of proteolipid domains and their functional relation during the cell process. If successful, this work will provide advanced understanding of molecular mechanism in stem cell process which will enable the control of the cell differentiation and proliferation at subcellular and molecular levels.

The work is financed from grants from the Knut and Alice Wallenberg Foundation and the University of Gothenburg.

1. has been awarded a second-cycle qualification, 2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or 3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad. To meet the specific entry requirements for third-cycle studies, applicants must: (i) have a second-cycle (advanced-level) degree in a relevant* subject area in the natural sciences, or (ii) have completed studies for at least 60 higher education credits at a second-cycle level in relevant subject areas in the natural sciences, or (iii) have completed a corresponding programme of relevance to the planned third-cycle programme, in Sweden or in another country, or have equivalent qualifications. The specific entry requirements also include an acceptable command of spoken and written English. Guidelines for assessing English proficiency may include a minimum score of 550 on the TOEFL test (or 213 on the TOEFL-CBT, or 79 on the TOEFL-iBT).

Regulations for the evaluation of qualifications for education on a doctoral level are given in SFS 1998:80.

Additional information about the assessment: Excellence, creativity, and a personality that is easy to work with are the main criteria. It is preferred that the candidate has some experience with STED microscopy, and/or stem cells culture and differentiation.

Type of employment: Fixed-term employment, Four years full time

Extent: 100 % Location: Department of Chemistry and Molecular Biology, Gothenburg First day of employment: 2019-08-01. Regulations for the evaluation of qualifications for education on a doctoral level are given in SFS 1998:80.

A new employment as a PhD student applies for a maximum of one year. The Appointment may be prolonged for up to two years at a time. The total employment period may not be longer than the equivalent of four years of full time time doctoral studies.

Cover letter with an explanation of why you apply for the position

CV including scientific publications Copy of exam certificate Two references (name, telephone no, relation) For further information regarding the position: Dr. Nhu Phan. Email: nhu.phan@chem.gu.se or Andrew Ewing. Email: Andrew.ewing@chem.gu.se.

Questions regarding the third-cycle education: Martin Billeter, Director of third cycle education, +46(0) 31-786 3925, martin.billeter@gu.se Questions regarding the employment: hr@cmb.gu.se Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salaries for doctoral students are regulated in a local agreement at the University.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

Deadline: June 15, 2019
Apply Link:http://tinyurl.com/y45v77ul

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