Postdoc Position at Imperial College London

Applications are invited for a postdoctoral researcher position to join Imperial College London, UK. This position is available for 36 months. This position is closed on May 12, 2019.

We are looking for an enthusiastic vascular Research Associate with a strong interest in patient- and disease-specific organ/tissue-models. This 3-year post is funded by the British Heart Foundation to investigate the role of Arf signaling in organ-on-a-chip model of pulmonary arterial hypertension (PAH).

PAH is an incurable disease, characterised by high blood pressure in the lung arteries. Activation of Arf GTPases contributes endothelial dysfunction in PAH. This project aims to identify the mechanism of Arf6-dependent changes in membrane receptor trafficking, identify strategies of Arf6 targeting and evaluate the effect of Arf6 activity changes on pulmonary vascular function in vitro, using cellular and translational approaches in a novel microfluidic pre-clinical platform, pulmonary artery-on-a-chip (https://www.youtube.com/watch?v=dqniQfROc9A).

The work combines expertise across a range of in vitro techniques, including cell culture, qRT PCR, molecular cloning, immunostaining/histochemistry, luciferase reporter assays, Western blotting, GTP-binding assays, scanning ion conductance microscopy, fluorescence confocal microscopy and image analysis.

You will be expected to submit publications to refereed journals and to attract external research funding.

You will join a multidisciplinary team of basic scientists and clinicians working on pathogenesis of pulmonary hypertension. You will help to generate new knowledge on disease aetiology, underlying biochemical pathways and mechanisms. Under the academic mentors' guidance, you will support the development of a new microfluidic platform for personalised medicine, pulmonary artery-on-a-chip.

This is a full-time, 36 months post, based at the Hammersmith Campus, Du Cane Road, London W12 0NN.

Should you require any further details on the role please contact: Dr Beata Wojciak-Stothard - b.wojciak-stothard@imperial.ac.uk.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published.For more information, seehttps://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College's care are treated with full respect, and that all staff involved with this work show due consideration at every level.

Deadline: May 12, 2019
Apply Link:http://tinyurl.com/y6dtqyeo

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