Postdoctoral Postdoc Position. at University of North Carolina Chapel Hill

University of North Carolina Chapel Hill, USA is inviting excellent candidates to apply for a postdoc position in cell biology. Applications will be evaluated on a continuous basis.

An NIH-funded post-doctoral position is available in the laboratory of Dr. Cyrus Vaziri in the Department of Pathology and Laboratory Medicine at UNC. The successful applicant will define novel pathological DNA repair mechanisms by which cancer cells mutate their genomes and resist therapy (see Nature Communications 7, 12105, 2016 PMID: 27377895; J Cell Biol 216, p3097 , 2017, PMID: 28835467; Vaziri lab web site: ) Molecular & cell biology, genetics, and biochemical & biophysical approaches will be used to determine how cancer cells reprogram DNA repair pathways. The work is inherently translational: defining the mechanistic and structural basis for pathological DNA repair will allow us to develop chemical probes and validate cancer-specific DNA repair factors as tractable therapeutic targets. These studies will be performed in collaboration with Dr. Ken Pearce ( at The UNC Center for Integrative Chemical Biology and Drug Discovery ( The close partnership with Dr. Pearce and the CICBDD will provide valuable experience with industrial approaches (e.g. development of high throughput and high-content screening platforms) for those applicants considering long-term careers in the pharmaceutical industry. The three coequal missions of the Department of Pathology and Laboratory Medicine are to: 1) provide exceptional, comprehensive, clinically effective and cost effective pathology and laboratory medicine services to UNC HealthCare patients; 2) teach clinical and scientific concepts of pathology and laboratory medicine, and mechanisms of disease to a wide variety of learners, including medical students, postdoctoral residents, MD fellows, PhD graduate students, and undergraduate students; and 3) advance the practice of pathology and laboratory medicine, and the knowledge of diseases and disease mechanisms through innovative research spanning the spectrum from basic to translational to clinical. The Department of Pathology and Lab Medicine performs anatomic and clinical diagnostic tests on both an inpatient and an outpatient basis, and performs autopsies, when requested by clinicians. The Department has a MD Residency Training Program in the Office of Graduate Medical Education. In the College of Arts and Sciences, the Department is responsible for the teaching of undergraduate level courses. In the Graduate School, the department has a graduate program in experimental pathology which offers both M.S. and Ph.D. degrees. This department is devoted to research in many diverse areas of expertise. Many of the research initiatives are nationally and internationally known, and the Chair is dedicated to further expansion of the breadth of the research endeavors. Most research is wholly managed and funded by contracts and grants within the Department.

Deadline: As soon as possible
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