PhD in Computational Quantification of Mechanical Interactions Cell-biomaterial

International students are invited for a PhD scholarship in computational biology at Eindhoven University of Technology. There is no application deadline for this position.

PhD position in the Quantification of Cell-Biomaterial Mechanical Interactions via Computational Methods, vacancy V50.3082.

The Eindhoven University of Technology (TU/e) is seeking an ambitious PhD candidate to investigate the quantification of the mechanical interactions between functionalized (bio)materials and living cells/tissues. Research carried out by the successful candidate will be part of greater and exciting efforts aiming at establishing a new Platform for the Live-Quantification of Cell and Tissue Mechanics at the TU/e.

TU/e is a University of Technology with a focus on Health, Energy and Mobility. Within the Health area, several departments cooperate on topics such as Chemical Biology, Regenerative Medicine, Computational Biology, and Biosensing, with close links to healthcare and industry. TU/e is an open and inclusive university with short communication lines. The people are curious, collaborative, and strive for excellence. TU/e enables its academic staff to develop research and education at an internationally renowned level. Our lively campus community facilitates connections between staff and students, in an open, friendly, vibrant atmosphere that welcomes and inspires.

The Department of Biomedical Engineering (BME) offers a research driven BME Bachelor program and Masters in Biomedical Engineering and Medical Engineering in its Graduate Program. Its research areas range from Molecular Bioengineering and Imaging, Biomechanics and Tissue Engineering to Biomedical Imaging and Modelling. The department has more than 800 students and up to 200 tenured and non-tenured employees.

The candidate will generate new computational algorithms to quantify the mechanical interactions between living cells/tissues and functionalized (bio)materials by means of advanced image-analysis methods and experimental techniques for cellular force inference (e.g. Traction Microscopy, Video Force Microscopy, Stress Microscopy and Laser Ablation). The successful candidate will build on pre-established analytical and finite-element computational algorithms to further develop new methodological approaches for the handling of novel experimental setups currently unavailable in the field. The PhD candidate is expected to do scientific research in the field described above, write a doctoral thesis and publish research results in scientific journals. An educational and professional development program is offered to all PhD candidates. A small part of the position involves teaching in courses offered by the group as well as to contribute to the co-supervision of bachelor and master students.

We are accepting applications from enthusiastic and highly talented candidates who are interested in a dynamic, stimulating and ambitious environment to perform their research.

The research will be mainly conducted within the Soft Tissue Engineering and Mechanobiology (STEM) group in the Department of Biomedical Engineering under the supervision of Dr Vito Conte and prof.dr. C.V.C. Bouten, who heads the STEM group. prof.dr. C.V.C. Bouten's STEM group concentrates on the study of disease progression as well as on the engineering of soft tissues, which are aimed at either the replacement of diseased or malformed tissues, or the development of in-vitro model systems of developing tissues. Results are used to conceive possible anti-cancer mechano-therapies as well as to design novel approaches of in situ tissue regeneration with principal application in the cardiovascular area (heart valves and vessels), organ regeneration (heart, cornea, and kidney). The group houses the Cell and Tissue Engineering laboratory, a shared research infrastructure operating at the international forefront of the engineering of living, load-bearing tissues.

Deadline: As soon as possible
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